Hematopoietic stem cell transplantation for adult sickle cell disease in the era of universal donor availibility
نویسندگان
چکیده
منابع مشابه
Alternative donor hematopoietic stem cell transplantation for sickle cell disease.
Most patients who could be cured of sickle cell disease (SCD) with stem cell transplantation do not have a matched sibling donor. Successful use of alternative donors, including mismatched family members, could provide a donor for almost all patients with SCD. The use of a reduced-intensity conditioning regimen may decrease late adverse effects. Ten patients with symptomatic SCD underwent CD34+...
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Sickle cell disease-related organ injuries cannot be prevented despite hydroxyurea use, infection prophylaxis, and supportive therapies. As a consequence, disease-related mortality reaches 14% in adolescents and young adults. Hematopoietic stem cell transplantation is a unique curative therapeutic approach for sickle cell disease. Myeloablative allogeneic hematopoietic stem cell transplantation...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2018
ISSN: 0268-3369,1476-5365
DOI: 10.1038/s41409-018-0193-6